Commonly Prescribed Drugs
Another common side effect associated with statin agents when used to dramatically reduce cholesterol levels are the neurodegenerative type diseases, almost like Lou Gehrig’s disease or Multiple sclerosis, and this is because there is damage to the cellular membranes that make up the insulation around the nerves. It is like electrical wiring in an old house where the insulation around the wire has broken down leaving exposed wiring. It just doesn’t work as well, and inadequate electrical supply and short circuiting becomes more common. These poorly functioning nerves and membranes result in muscle aches/pains as well as decrease strength and decreased nerve function. Memory and thought process may also be severely affected.
Dr. Graveline points out that we are all at risk when the general public is taking statins–do you want to be in an airplane when your pilot develops statin-induced amnesia?
It seems that a lot of these problems begin when cholesterol levels become elevated and aggressive reduction occurs with the use of statin agents.
Therefore elevated cholesterol levels have been described as the initiating phase in the development of atherosclerosis. Lipitor also blocks the important production of coenzyme q-10, which is necessary to maintain heart muscle health and energy. In women with low coenzyme q-10 levels the incidence of breast cancer is markedly increased. The importance of coenzyme Q-10 is derived from its ability to provide energy to the body. It helps process ATP, and transports it into the cells. Coenzyme q-10 is very beneficial in patients with cardiomyopathies from heart damage, because they are chronically starved for energy. By introducing coenzyme q-10, the energy producing ATP is express delivered into the energy starved heart muscle cells.
Co-enzyme Q-10, is a vitamin like substance and is found in all cells, and it is critical for the production of energy. In fact, 95 % of all energy made by our cells is produced with the assistance of Co-enzyme Q-10. Organs that need an incredible amount of energy to function, such as the heart, lungs, and liver will have the highest concentration of Q-10.
If you are still wondering why it is so important, let’s look at these facts. Studies have shown that the use of statin agents for cholesterol control will reduce the level of co-enzyme q-10 by up to 40%, and that by replacing the coenzyme, the muscle aches that are so prevalent with statin therapy disappear. It appears that these statin agents, by altering membrane function actually also impair energy transport to these muscles to keep them functioning properly. Co-enzyme q-10 has also been used in patients with congestive heart failure and this is related to providing energy through ATP to damaged, poorly functioning, energy starved cells. It has also been used in patients on the list for heart transplant, and allows them to safely wait until a heart is available without going into heart failure. Recent reports have also shown improvement in ejection fraction, stroke volume, cardiac index and exercise tolerance. Other studies have been performed to evaluate the benefit of coenzyme Q-10 in patients undergoing heart surgery. It has been shown to improve cardiac function after coronary artery bypass or valve replacement. I like use Coenzyme Q-10 in conjunction with D-ribose on my off-pump coronary bypass patients. When operating on a heart that is still beating, one needs to cause localized ischemia or lack of blood flow to the area that you are operating on. This repeated ischemia causes the heart to not function as well after repeated bypasses, as it leaks all its ATP out of the muscle cells. Adding Co-Q10 and ribose stabilizes this loss and allows coronary artery bypass to be performed safely without ever stopping the heart.
Why does the serum cholesterol levels seem to increase as patients reach their 40’s and 50’s? Is it because when we were in our 20’s we ate so carefully, and now that we approach our 50’s we are ambivalent about our diet? I would suspect that is quite the opposite, but then why do the levels increase? The classic stressed type A business man seems to be the poster child for elevated cholesterol and the increased development of heart disease. Why is that? Diet and exercise or lack of certainly play critical roles in this process but how does our body deal with stress? Cortisol and DHEA levels sky-rocket in the face of stress, and in some patients, remain constantly elevated throughout the entire day. Our body has to produce these stress hormones and how does it do it. The precursor, or beginning compound for all of the stress and sex hormones is cholesterol(figure
1). Steroid hormones reduced by statin therapy include Pregnenolone, Progesterone, Estrogen,Testosterone, Aldosteroen, Cortisol and DHEA. Therefore, to compensate for the tremendous need for managing stress, the body and all its very complicated synthetic processes signal the need to appropriately produce more cholesterol. Unfortunately, as physicians, our response is to block that appropriate response mechanism in an attempt to protect the patient from presumed heart disease.
When women develop menopause, and men develop andropause, the body appropriately compensates by signaling the increased production of cholesterol(figure 1), as well as the increased absorption through the gastrointestinal system. The subsequent increase in cholesterol provides precursor molecules for the body to try and produce the needed sex hormones. In men, studies have shown that testosterone replacement therapy will reduce cholesterol levels, and in fact have been shown to reduce insulin resistance and the metabolic syndrome. Proper hormone replacement in women with progesterone and estrogen also results in the reduction of LDL cholesterol. The meticulous feedback mechanisms demonstrated throughout our body are manifested by responsive cholesterol levels. So why do we try and disrupt these mechanisms? The aggressive lowering of total cholesterol below 140 mg/dl will result in the dramatic reduction of testosterone production in males with a resultant drug induced andropause and its associated depression and fatigue.
Of course, statins inhibit the production of cholesterol–they do this very well. Cholesterol is the body’s repair substance: scar tissue contains high levels of cholesterol, including scar tissue in the arteries.
Cholesterol is the precursor to vitamin D(see figure 1), necessary for numerous biochemical processes including mineral metabolism. The use of statin agents will reduce the synthesis of Vitamin D. Studies have identified the increased incidence of musculoskeletal pain in patients who are vitamin D deficient, and that replacement results in dramatic improvement.(Al Faraj S.,et al. Vitamin D Deficiency and chronic low back pain in Saudi Arabia,” Spine 2003; 28(2): 177-9). Vitamin D has also been shown to dramatic reduce the incidence of cancer in postmenopausal women.( Lappe, American Journal of Clinical Nutrition 2007).
A number of patients describe gastrointestinal symptoms and diarrhea associated with statin therapy. Unfortunately after an extensive gastrointestinal workup, the stain therapy is not discontinued. Statin agents reduce bile salts production, which is required for the digestion of fat.(Figure 1). Those who suffer from low cholesterol often have trouble digesting fats. Cholesterol also functions as a powerful antioxidant, thus protecting us against cancer and aging.
Cholesterol is vital to proper neurological function. It plays a key role in the formation of memory and the uptake of hormones in the brain, including serotonin. When cholesterol levels drop too low, the serotonin receptors cannot function properly. Cholesterol is the main organic molecule in the brain, constituting over half the dry weight of the cerebral cortex, and critical in maintaining cell membranes and the integrity of the nervous system by producing myelin.
It is no surprise that the aggressive control of cholesterol in an attempt to reduce cardiovascular disease, in itself produces it’s own disease process.
Dr. Robert G. Carlson, MD FACS